X-ray diffraction
2.9Å resolution

Crystal structure of the kinase domain of ROR2

Source organism: Homo sapiens
Entry authors: Tresaugues L, Moche M, Arrowsmith CH, Berglund H, Bountra C, Edwards AM, Ekblad T, Graslund S, Karlberg T, Nyman T, Schuler H, Thorsell AG, Weigelt J, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase transmembrane receptor ROR2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 289 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q01974 (Residues: 463-751; Coverage: 32%)
Gene names: NTRKR2, ROR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 55.613Å b: 61.301Å c: 79.936Å
α: 90° β: 93.07° γ: 90°
R R work R free
0.19 0.187 0.247
Expression system: Spodoptera frugiperda