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Crystal structure of a tetrameric acetylglutamate kinase from Saccharomyces cerevisiae

Source organism: Saccharomyces cerevisiae
Biochemical function: acetylglutamate kinase activity
Biological process: arginine biosynthetic process
Cellular component: cytoplasm

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EC 2.7.2.8: Acetylglutamate kinase

Reaction catalysed:
ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate
Systematic name:
ATP:N-acetyl-L-glutamate 5-phosphotransferase
Alternative Name(s):
  • Acetylglutamate phosphokinase
  • N-acetylglutamate 5-phosphotransferase
  • N-acetylglutamate kinase
  • N-acetylglutamate phosphokinase
  • N-acetylglutamic 5-phosphotransferase

EC 1.2.1.38: N-acetyl-gamma-glutamyl-phosphate reductase

Reaction catalysed:
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-L-glutamyl 5-phosphate + NADPH
Systematic name:
N-acetyl-L-glutamate-5-semialdehyde:NADP(+) 5-oxidoreductase (phosphorylating)
Alternative Name(s):
  • N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
  • N-acetyl-glutamate semialdehyde dehydrogenase
  • N-acetylglutamate 5-semialdehyde dehydrogenase
  • N-acetylglutamic gamma-semialdehyde dehydrogenase
  • NAGSA dehydrogenase
  • Reductase, acetyl-gamma-glutamyl phosphate

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF04768
Domain description: NAT, N-acetyltransferase, of N-acetylglutamate synthase
Occurring in:
  1. Acetylglutamate kinase
The deposited structure of PDB entry 3zzi contains 8 copies of Pfam domain PF04768 (NAT, N-acetyltransferase, of N-acetylglutamate synthase) in Acetylglutamate kinase. Showing 1 copy in chain A.

PF00696
Domain description: Amino acid kinase family
Occurring in:
  1. Acetylglutamate kinase
The deposited structure of PDB entry 3zzi contains 8 copies of Pfam domain PF00696 (Amino acid kinase family) in Acetylglutamate kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006855
Domain description: Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
Occurring in:
  1. Acetylglutamate kinase
IPR036393
Domain description: Acetylglutamate kinase-like superfamily
Occurring in:
  1. Acetylglutamate kinase
IPR041734
Domain description: N-Acetyl-L-glutamate kinase, fungal-type
Occurring in:
  1. Acetylglutamate kinase
IPR001048
Domain description: Aspartate/glutamate/uridylate kinase
Occurring in:
  1. Acetylglutamate kinase
IPR004662
Domain description: Acetylglutamate kinase family
Occurring in:
  1. Acetylglutamate kinase
IPR011242
Domain description: Acetylglutamate kinase ArgB, GNAT domain-containing
Occurring in:
  1. Acetylglutamate kinase

Structure domains

CATH CATH domains
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Acetylglutamate kinase
The deposited structure of PDB entry 3zzi contains 8 copies of CATH domain 3.40.630.30 (Aminopeptidase) in Acetylglutamate kinase. Showing 1 copy in chain A.
3.40.1160.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Carbamate kinase
Homology: Acetylglutamate kinase-like
Occurring in:
  1. Acetylglutamate kinase
The deposited structure of PDB entry 3zzi contains 8 copies of CATH domain 3.40.1160.10 (Carbamate kinase) in Acetylglutamate kinase. Showing 1 copy in chain A.

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