3zyu

X-ray diffraction
1.5Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with I-BET151(GSK1210151A)

Released:
Source organism: Homo sapiens
Entry authors: Chung CW, Mirguet O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 41.894Å b: 59.542Å c: 109.195Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.164 0.162 0.201
Expression system: Escherichia coli