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Crystal structure of human mitochondrial tyrosyl-tRNA synthetase in complex with a tyrosyl-adenylate analog

X-ray diffraction
2.75Å resolution
PDB entry 3zxi coloured by chain, front view.
PDB entry 3zxi coloured by chain, side view.
PDB entry 3zxi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine--tRNA ligase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 26463.38 Å2
Buried surface area: 4812.63 Å2
Dissociation area: 1,449.34 Å2
Dissociation energy (ΔGdiss): 19.72 kcal/mol
Dissociation entropy (TΔSdiss): 13.6 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195175

Macromolecules

Tyrosine--tRNA ligase, mitochondrial
Chains: A, B
Length: 356 amino acids
Theoretical weight: 39.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y2Z4 (Residues: 32-375; Coverage: 72%)
Gene names: CGI-04, YARS2
Pfam: tRNA synthetases class I (W and Y)
InterPro:
CATH:
Tyrosine--tRNA ligase, mitochondrial in PDB entry 3zxi, assembly 1, front view.
Tyrosine--tRNA ligase, mitochondrial in PDB entry 3zxi, assembly 1, side view.
Tyrosine--tRNA ligase, mitochondrial in PDB entry 3zxi, assembly 1, top view.
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