› › Structure analysis

LSD1-CoREST in complex with PLSFLV peptide

X-ray diffraction
3Å resolution
PDB entry 3zmv coloured by chain, front view.
PDB entry 3zmv coloured by chain, side view.
PDB entry 3zmv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 37716.03 Å2
Buried surface area: 8732.06 Å2
Dissociation area: 331.11 Å2
Dissociation energy (ΔGdiss): 0.89 kcal/mol
Dissociation entropy (TΔSdiss): 5.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129952

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 872 amino acids
Theoretical weight: 94.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60341 (Residues: 1-173, 174-852; Coverage: 100%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
InterPro:
CATH:
Lysine-specific histone demethylase 1A in PDB entry 3zmv, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 3zmv, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 3zmv, assembly 1, top view.
Molecule details ›

Search similar proteins

REST corepressor 1
Chain: B
Length: 482 amino acids
Theoretical weight: 53.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UKL0 (Residues: 4-485; Coverage: 99%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
REST corepressor 1 in PDB entry 3zmv, assembly 1, front view.
REST corepressor 1 in PDB entry 3zmv, assembly 1, side view.
REST corepressor 1 in PDB entry 3zmv, assembly 1, top view.
Molecule details ›

Search similar proteins

PKSFLV PEPTIDE
Chains: C, D
Length: 6 amino acids
Theoretical weight: 675 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
PKSFLV PEPTIDE in PDB entry 3zmv, assembly 1, front view.
PKSFLV PEPTIDE in PDB entry 3zmv, assembly 1, side view.
PKSFLV PEPTIDE in PDB entry 3zmv, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links