3zi0

X-ray diffraction
1.9Å resolution

Structure of Mycobacterium tuberculosis DXR in complex with a fosmidomycin analogue

Released:
Entry authors: Bjorkelid C, Jansson AM, Bergfors T, Unge T, Mowbray SL, Jones TA

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-deoxy-D-xylulose 5-phosphate reductoisomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 397 amino acids
Theoretical weight: 41.6 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WNS1 (Residues: 2-389; Coverage: 94%)
Gene names: MTCY274.01c, Rv2870c, dxr
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 67.447Å b: 68.707Å c: 85.7Å
α: 90° β: 107.34° γ: 90°
R-values:
R R work R free
0.206 0.205 0.231
Expression system: Escherichia coli BL21(DE3)