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Molecular basis for the action of the collagen-specific chaperone Hsp47 SERPINH1 and its structure-specific client recognition.

Source organisms:
Biochemical function: collagen binding
Biological process: collagen fibril organization
Cellular component: endoplasmic reticulum

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00079
Domain description: Serpin (serine protease inhibitor)
Occurring in:
  1. Serpin H1
The deposited structure of PDB entry 3zha contains 8 copies of Pfam domain PF00079 (Serpin (serine protease inhibitor)) in Serpin H1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023796
Domain description: Serpin domain
Occurring in:
  1. Serpin H1
IPR033830
Domain description: Serpin H1, serpin domain
Occurring in:
  1. Serpin H1
IPR023795
Domain description: Serpin, conserved site
Occurring in:
  1. Serpin H1
IPR042185
Domain description: Serpin superfamily, domain 2
Occurring in:
  1. Serpin H1
IPR042178
Domain description: Serpin superfamily, domain 1
Occurring in:
  1. Serpin H1
IPR000215
Domain description: Serpin family
Occurring in:
  1. Serpin H1
IPR036186
Domain description: Serpin superfamily
Occurring in:
  1. Serpin H1

Structure domains

CATH CATH domains
2.30.39.10
Class: Mainly Beta
Architecture: Roll
Topology: Alpha-1-antitrypsin; domain 1
Homology: Alpha-1-antitrypsin, domain 1
Occurring in:
  1. Serpin H1
The deposited structure of PDB entry 3zha contains 8 copies of CATH domain 2.30.39.10 (Alpha-1-antitrypsin; domain 1) in Serpin H1. Showing 1 copy in chain A.
3.30.497.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Antithrombin; Chain I, domain 2
Homology: Antithrombin, subunit I, domain 2
Occurring in:
  1. Serpin H1
The deposited structure of PDB entry 3zha contains 8 copies of CATH domain 3.30.497.10 (Antithrombin; Chain I, domain 2) in Serpin H1. Showing 1 copy in chain A.

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