X-ray diffraction
2.9Å resolution

Crystal structure of the TPR domain of kinesin light chain 2 in complex with a tryptophan-acidic cargo peptide

Source organisms:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kinesin light chain 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O88448 (Residues: 217-430, 431-478; Coverage: 44%)
Gene name: Klc2
Sequence domains:
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Pleckstrin homology domain-containing family M member 2 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 45 amino acids
Theoretical weight: 4.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8IWE5 (Residues: 203-212; Coverage: 1%)
Gene names: KIAA0842, PLEKHM2, SKIP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21212
Unit cell:
a: 87.81Å b: 90.86Å c: 94.04Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.244
Expression system: Escherichia coli BL21(DE3)