3ze0

X-ray diffraction
2.95Å resolution

Integrin alphaIIB beta3 headpiece and RGD peptide complex

Released:
Source organisms:
Primary publication:
Complete integrin headpiece opening in eight steps.
OpenAccess logo J. Cell Biol. 201 1053-68 (2013)
PMID: 23798730

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Integrin alpha-IIb heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 457 amino acids
Theoretical weight: 49.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-488; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 472 amino acids
Theoretical weight: 52.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-498; Coverage: 62%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:
10E5 FAB HEAVY CHAIN Chains: E, H
Molecule details ›
Chains: E, H
Length: 221 amino acids
Theoretical weight: 23.77 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
10E5 FAB LIGHT CHAIN Chains: F, L
Molecule details ›
Chains: F, L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
RGD PEPTIDE Chains: I, J
Molecule details ›
Chains: I, J
Length: 6 amino acids
Theoretical weight: 589 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID
Spacegroup: P21212
Unit cell:
a: 259.64Å b: 144.68Å c: 104.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.185 0.243
Expression systems:
  • Cricetulus griseus
  • Mus musculus
  • Not provided