Structure analysis

S266A mutant 3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580MPa - complex with IPM and Mg

X-ray diffraction
1.55Å resolution
Source organism: Shewanella oneidensis MR-1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 26100 Å2
Buried surface area: 6400 Å2
Dissociation area: 2,700 Å2
Dissociation energy (ΔGdiss): 40 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -35 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 375 amino acids
Theoretical weight: 40.67 KDa
Source organism: Shewanella oneidensis MR-1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8E9N3 (Residues: 2-364; Coverage: 100%)
Gene names: SO_4235, leuB
Pfam: Isocitrate/isopropylmalate dehydrogenase
InterPro:
CATH: Isopropylmalate Dehydrogenase

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