X-ray diffraction
2.16Å resolution

Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with NAD


Function and Biology Details

Reaction catalysed:
A primary alcohol + NAD(+) = an aldehyde + NADH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
PKS_ER domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 341 amino acids
Theoretical weight: 36.35 KDa
Source organism: Candida parapsilosis
Expression system: Escherichia coli
  • Canonical: A1X808 (Residues: 1-336; Coverage: 100%)
Gene names: CPRADH, rCR
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NAD 4 x NAD
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 85.641Å b: 106.105Å c: 145.55Å
α: 90° β: 90° γ: 90°
R R work R free
0.183 0.181 0.216
Expression system: Escherichia coli