› 3wlb

X-ray diffraction
2Å resolution

HLA-A24 in complex with HIV-1 Nef126-10(8T10F)

Released:
DOI: 10.2210/pdb3wlb/pdb
PDB entry 3wlb coloured by chain, front view.
PDB entry 3wlb coloured by chain, side view.
PDB entry 3wlb coloured by chain, top view.
Source organisms:
Primary publication:
Switching and emergence of CTL epitopes in HIV-1 infection.
Han C, Kawana-Tachikawa A, Shimizu A, Zhu D, Nakamura H, Adachi E, Kikuchi T, Koga M, Koibuchi T, Gao GF, Sato Y, Yamagata A, Martin E, Fukai S, Brumme ZL, Iwamoto A
Retrovirology 11 38 (2014)
PMID: 24886641

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137819 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
C-terminal core protein Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 1.11 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q77378 (Residues: 132-141; Coverage: 5%)
Gene name: nef

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 67.084Å b: 77.725Å c: 87.097Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.171 0.245
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure.
Avila-Rios et al. (2019)
9 other articles

1 mention without citation

SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage.
Karami Fath et al. (2021)