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Crystal structure of the SepCysS-SepCysE complex from Methanocaldococcus jannaschii

Source organism: Methanocaldococcus jannaschii DSM 2661
Biochemical function: Sep-tRNA:Cys-tRNA synthase activity
Biological process: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA
Cellular component: not assigned

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EC 2.5.1.73: O-phospho-L-seryl-tRNA:Cys-tRNA synthase

Reaction catalysed:
O-phospho-L-seryl-tRNA(Cys) + sulfide = L-cysteinyl-tRNA(Cys) + phosphate
Systematic name:
O-phospho-L-seryl-tRNA(Cys):hydrogen sulfide 2-aminopropanoate transferase
Alternative Name(s):
  • Sep-tRNA:Cys-tRNA synthase
  • SepCysS

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09873
Domain description: Uncharacterized protein conserved in archaea (DUF2100)
Occurring in:
  1. Uncharacterized protein MJ1481
The deposited structure of PDB entry 3wkr contains 4 copies of Pfam domain PF09873 (Uncharacterized protein conserved in archaea (DUF2100)) in Uncharacterized protein MJ1481. Showing 1 copy in chain G.

PF05889
Domain description: O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
The deposited structure of PDB entry 3wkr contains 4 copies of Pfam domain PF05889 (O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS) in O-phospho-L-seryl-tRNA:Cys-tRNA synthase. Showing 1 copy in chain E.

InterPro InterPro annotations
IPR016736
Domain description: Uncharacterised protein MJ1481, archaea
Occurring in:
  1. Uncharacterized protein MJ1481
IPR013375
Domain description: O-phosphoseryl-tRNA:Cys-tRNA synthase, archaea
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
IPR008829
Domain description: SepSecS/SepCysS family
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
The deposited structure of PDB entry 3wkr contains 4 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in O-phospho-L-seryl-tRNA:Cys-tRNA synthase. Showing 1 copy in chain E.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. O-phospho-L-seryl-tRNA:Cys-tRNA synthase
The deposited structure of PDB entry 3wkr contains 4 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in O-phospho-L-seryl-tRNA:Cys-tRNA synthase. Showing 1 copy in chain E.

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