3whe

X-ray diffraction
4Å resolution

A new conserved neutralizing epitope at the globular head of hemagglutinin in H3N2 influenza viruses

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only nonamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Hemagglutinin Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 493 amino acids
Theoretical weight: 55.22 KDa
Source organism: Influenza A virus (A/Aichi/2-1/1968(H3N2))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: T2HNI1 (Residues: 25-517; Coverage: 87%)
Gene name: HA
Structure domains:
immunoglobulin heavy chain Chains: 1, 3, 5, 7, 9, M, O, Q, S, U, W, Y
Molecule details ›
Chains: 1, 3, 5, 7, 9, M, O, Q, S, U, W, Y
Length: 226 amino acids
Theoretical weight: 24.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
immunoglobulin light chain Chains: 0, 2, 4, 6, 8, N, P, R, T, V, X, Z
Molecule details ›
Chains: 0, 2, 4, 6, 8, N, P, R, T, V, X, Z
Length: 220 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 391.037Å b: 241.173Å c: 223.214Å
α: 90° β: 123.62° γ: 90°
R-values:
R R work R free
0.236 0.235 0.308
Expression systems:
  • Spodoptera frugiperda
  • Cricetulus griseus