› 3wha

X-ray diffraction
1.3Å resolution

Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor

Released:
DOI: 10.2210/pdb3wha/pdb
PDB 3wha coloured by chain and viewed from the front.
PDB 3wha coloured by chain and viewed from the side.
PDB 3wha coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Fukami TA, Ono N

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

3 bound ligands:
Ligand GOL 1 x GOL
Ligand WHA 2 x WHA
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 107.17Å b: 98.92Å c: 64.24Å
α: 90° β: 124.55° γ: 90°
R-values:
R R work R free
0.185 0.184 0.2
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells.
Liu et al. (2015)
5 more