3wch

X-ray diffraction
2.5Å resolution

The complex structure of HsSQS wtih ligand BPH1237

Released:

Function and Biology Details

Reaction catalysed:
(1a) 2 farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo hexamer
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Squalene synthase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 360 amino acids
Theoretical weight: 41.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37268 (Residues: 31-370; Coverage: 82%)
  • Best match: P37268-2 (Residues: 1-306)
Gene name: FDFT1
Sequence domains: Squalene/phytoene synthase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P21
Unit cell:
a: 85.63Å b: 153.55Å c: 90.4Å
α: 90° β: 91.18° γ: 90°
R-values:
R R work R free
0.192 0.192 0.25
Expression system: Escherichia coli