X-ray diffraction
3.15Å resolution

Structural basis for the inhibition of bacterial multidrug exporters


Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Multidrug resistance protein MexB Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 1052 amino acids
Theoretical weight: 113.71 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli
  • Canonical: P52002 (Residues: 1-1046; Coverage: 100%)
Gene names: PA0426, mexB
Sequence domains: AcrB/AcrD/AcrF family
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P1
Unit cell:
a: 126.204Å b: 137.034Å c: 152.275Å
α: 85.75° β: 68.93° γ: 87.39°
R R work R free
0.206 0.202 0.279
Expression system: Escherichia coli