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Crystal structure of human Dlp1 in complex with GMP-PN.Pi

Source organism: Homo sapiens
Biochemical function: GTP binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.5.5: Dynamin GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (vesicle-releasing)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01031
Domain description: Dynamin central region
Occurring in:
  1. Dynamin-1-like protein
The deposited structure of PDB entry 3w6n contains 2 copies of Pfam domain PF01031 (Dynamin central region) in Dynamin-1-like protein. Showing 1 copy in chain B.

PF00350
Domain description: Dynamin family
Occurring in:
  1. Dynamin-1-like protein
The deposited structure of PDB entry 3w6n contains 2 copies of Pfam domain PF00350 (Dynamin family) in Dynamin-1-like protein. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR022812
Domain description: Dynamin
Occurring in:
  1. Dynamin-1-like protein
IPR001401
Domain description: Dynamin, GTPase domain
Occurring in:
  1. Dynamin-1-like protein
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Dynamin-1-like protein
IPR000375
Domain description: Dynamin stalk domain
Occurring in:
  1. Dynamin-1-like protein
IPR019762
Domain description: Dynamin, GTPase region, conserved site
Occurring in:
  1. Dynamin-1-like protein
IPR045063
Domain description: Dynamin, N-terminal
Occurring in:
  1. Dynamin-1-like protein
IPR030381
Domain description: Dynamin-type guanine nucleotide-binding (G) domain
Occurring in:
  1. Dynamin-1-like protein

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Dynamin-1-like protein
The deposited structure of PDB entry 3w6n contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Dynamin-1-like protein. Showing 1 copy in chain B.

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