3w2c

X-ray diffraction
2.45Å resolution

Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV

Released:
Source organism: Homo sapiens
Entry authors: Oliveira TM, Kairies NA, Engh RA

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 261 amino acids
Theoretical weight: 30.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 128-388; Coverage: 65%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 69.21Å b: 86.05Å c: 85.96Å
α: 90° β: 89.83° γ: 90°
R-values:
R R work R free
0.256 0.253 0.32
Expression system: Escherichia coli