Structure analysis

Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7

X-ray diffraction
4.303Å resolution
Source organisms:
Assembly composition:
Non-polymer only hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: Non-polymer only hexamer
Accessible surface area: 27200 Å2
Buried surface area: 8700 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 24 kcal/mol
Interface energy (ΔGint): -17 kcal/mol
Symmetry number: 1

Macromolecules

Chain: E
Length: 310 amino acids
Theoretical weight: 35.5 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06213 (Residues: 28-337; Coverage: 23%)
Gene name: INSR
Pfam: Receptor L domain
InterPro:

Search similar proteins

Chain: C
Length: 116 amino acids
Theoretical weight: 12.71 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:

Search similar proteins

Chain: D
Length: 114 amino acids
Theoretical weight: 12.68 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:

Search similar proteins

Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:

Search similar proteins

Chain: B
Length: 26 amino acids
Theoretical weight: 2.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-49; Coverage: 29%)
Gene name: INS
InterPro:

Search similar proteins

Chain: F
Length: 23 amino acids
Theoretical weight: 2.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P06213 (Residues: 724-746; Coverage: 2%)
  • Best match: P06213-2 (Residues: 724-746)
Gene name: INSR

Search similar proteins