3vzd

X-ray diffraction
2.3Å resolution

Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP

Released:

Function and Biology Details

Reaction catalysed:
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sphingosine kinase 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 361 amino acids
Theoretical weight: 39.92 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NYA1 (Residues: 9-364; Coverage: 93%)
Gene names: SK1, SPHK, SPHK1, SPK
Sequence domains: Diacylglycerol kinase catalytic domain
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 102.202Å b: 106.573Å c: 226.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.269
Expression system: Not provided