X-ray diffraction
2Å resolution

Crystal structure of Sphingosine Kinase 1


Function and Biology Details

Reaction catalysed:
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Sphingosine kinase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 360 amino acids
Theoretical weight: 39.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9NYA1 (Residues: 9-364; Coverage: 93%)
Gene names: SK1, SPHK, SPHK1, SPK
Sequence domains: Diacylglycerol kinase catalytic domain
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 101.859Å b: 226.263Å c: 106.487Å
α: 90° β: 90° γ: 90°
R R work R free
0.215 0.213 0.262
Expression system: Not provided