Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
A20p37 and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-143343 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ubiquitin
Molecule details ›
Chains: A, B, C
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P0CG48 (Residues: 609-684; Coverage: 11%)
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
A20p37
Molecule details ›
Chains: D, E, F
Length: 35 amino acids
Theoretical weight: 3.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: A20-like zinc finger
Length: 35 amino acids
Theoretical weight: 3.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P21580 (Residues: 757-790; Coverage: 4%)
Sequence domains: A20-like zinc finger
