Structure analysis

Human renin in complex with compound 18

X-ray diffraction
2.8Å resolution
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14500 Å2
Buried surface area: 1300 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 14400 Å2
Buried surface area: 1300 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): 0 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: homo hexamer
Accessible surface area: 71600 Å2
Buried surface area: 22900 Å2
Dissociation area: 5,600 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 44 kcal/mol
Interface energy (ΔGint): -66 kcal/mol
Symmetry number: 3

Macromolecules

Chains: A, B
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases

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