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Human renin in complex with compound 18

X-ray diffraction
2.8Å resolution
PDB 3vsx coloured by chain and viewed from the front.
PDB 3vsx coloured by chain and viewed from the side.
PDB 3vsx coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14500 Å2
Buried surface area: 1300 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 14400 Å2
Buried surface area: 1300 Å2
Dissociation area: 550 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): 0 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: homo hexamer
Accessible surface area: 71600 Å2
Buried surface area: 22900 Å2
Dissociation area: 5,600 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 44 kcal/mol
Interface energy (ΔGint): -66 kcal/mol
Symmetry number: 3

Macromolecules

Renin
Chains: A, B
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
PDB 3vsx contains 1 copy of Renin in assembly 1. This protein is highlighted and viewed from the front.
PDB 3vsx contains 1 copy of Renin in assembly 1. This protein is highlighted and viewed from the side.
PDB 3vsx contains 1 copy of Renin in assembly 1. This protein is highlighted and viewed from the top.
Molecule details ›

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