› 3via

X-ray diffraction
1.75Å resolution

Crystal structure of the PH domain of Evectin-2 from human

Released:
DOI: 10.2210/pdb3via/pdb
PDB entry 3via coloured by chain, front view.
PDB entry 3via coloured by chain, side view.
PDB entry 3via coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the strict phospholipid binding specificity of the pleckstrin homology domain of human evectin-2.
Okazaki S, Kato R, Uchida Y, Taguchi T, Arai H, Wakatsuki S
Acta Crystallogr D Biol Crystallogr 68 117-23 (2012)
PMID: 22281740

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-188417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin homology domain-containing family B member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 13.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96CS7 (Residues: 1-110; Coverage: 50%)
Gene names: EVT2, PLEKHB2
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 34.283Å b: 54.267Å c: 111.638Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.22 0.259
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Distribution, dynamics and functional roles of phosphatidylserine within the cell.
Kay et al. (2019)
4 more

1 mention without citation

The inner membrane complex sub-compartment proteins critical for replication of the apicomplexan parasite Toxoplasma gondii adopt a pleckstrin homology fold.
Tonkin et al. (2014)