3vi3

X-ray diffraction
2.9Å resolution

Crystal structure of alpha5beta1 integrin headpiece (ligand-free form)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-5 heavy chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 632 amino acids
Theoretical weight: 68.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08648 (Residues: 42-664; Coverage: 62%)
Gene names: FNRA, ITGA5
Sequence domains: FG-GAP repeat
Structure domains:
Integrin beta-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 454 amino acids
Theoretical weight: 50.56 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05556 (Residues: 21-465; Coverage: 57%)
Gene names: FNRB, ITGB1, MDF2, MSK12
Sequence domains:
Structure domains:
SG/19 Fab fragment (Light chain) Chains: E, L
Molecule details ›
Chains: E, L
Length: 219 amino acids
Theoretical weight: 24.22 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
SG/19 Fab fragment (Heavy chain) Chains: F, H
Molecule details ›
Chains: F, H
Length: 218 amino acids
Theoretical weight: 23.48 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P1
Unit cell:
a: 92.956Å b: 102.805Å c: 125.079Å
α: 76.1° β: 70.19° γ: 71.28°
R-values:
R R work R free
0.21 0.207 0.267
Expression systems:
  • Cricetulus griseus
  • Mus musculus