3vga

X-ray diffraction
3.1Å resolution

Crystal structure of human adenosine A2A receptor with an allosteric inverse-agonist antibody at 3.1 A resolution

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adenosine receptor A2a Chain: A
Molecule details ›
Chain: A
Length: 326 amino acids
Theoretical weight: 36.54 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P29274 (Residues: 1-316; Coverage: 77%)
Gene names: ADORA2, ADORA2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhopdopsin 7-helix transmembrane proteins
antibody fab fragment light chain Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 23.53 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
antibody fab fragment heavy chain Chain: C
Molecule details ›
Chain: C
Length: 226 amino acids
Theoretical weight: 24.29 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 120.313Å b: 89.766Å c: 110.682Å
α: 90° β: 96.14° γ: 90°
R-values:
R R work R free
0.199 0.196 0.263
Expression system: Komagataella pastoris