PDB 3veu biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Beta-secretase 1
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-157541

$Monomeric assembly 1 of PDB entry 3veu coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Beta-secretase 1;</li> <li class='image_legend_li'>1 copy of (2S)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-{[3-(propan-2-yl)benzyl]amino}butan-2-yl]-2-[(5S)-6-oxo-1-propyl-1,7-diazaspiro[4.4]non-7-yl]propanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3veu coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Beta-secretase 1;</li> <li class='image_legend_li'>1 copy of (2S)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-{[3-(propan-2-yl)benzyl]amino}butan-2-yl]-2-[(5S)-6-oxo-1-propyl-1,7-diazaspiro[4.4]non-7-yl]propanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3veu coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Beta-secretase 1;</li> <li class='image_legend_li'>1 copy of (2S)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-{[3-(propan-2-yl)benzyl]amino}butan-2-yl]-2-[(5S)-6-oxo-1-propyl-1,7-diazaspiro[4.4]non-7-yl]propanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Beta-secretase 1

Chain: A
Length: 402 amino acids
Theoretical weight: 44.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P56817 (Residues: 48-447; Coverage: 83%)

Gene names: BACE, BACE1, KIAA1149
Pfam: Eukaryotic aspartyl protease
InterPro:

Aspartic peptidase domain superfamily
Aspartic peptidase A1 family
Memapsin-like
Peptidase family A1 domain
Aspartic peptidase, active site
Beta-secretase BACE1
Beta-secretase BACE

CATH: Acid Proteases

Beta-secretase 1 in PDB entry 3veu, assembly 1, front view.

Beta-secretase 1 in PDB entry 3veu, assembly 1, side view.

Beta-secretase 1 in PDB entry 3veu, assembly 1, top view.

FASTA Sequence


    >pdb|3veu|A

GPDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI

PDBe-KB: UniProt Coverage View: P56817

Molecule details ›

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FASTA (Protein chains A)
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PDBML
PDBML (ATOM lines)
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Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P56817 (UniProt)

Protein Data Bank in Europe

Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326

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Assemblies

Assembly 1 (preferred)

Macromolecules

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PDBe › 3veu › Structure analysis

Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326

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Assemblies

Assembly 1 (preferred)

Macromolecules

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3veu › Structure analysis