X-ray diffraction
2.5Å resolution

Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 566 amino acids
Theoretical weight: 62.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P30038 (Residues: 18-563; Coverage: 97%)
  • Best match: P30038-2 (Residues: 1-503)
Gene names: ALDH4, ALDH4A1, P5CDH
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P65
Unit cell:
a: 150.717Å b: 150.717Å c: 191.98Å
α: 90° β: 90° γ: 120°
R R work R free
0.205 0.204 0.238
Expression system: Escherichia coli BL21(DE3)