PDB 3v6r biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Mitogen-activated protein kinase 10
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-156874

$Monomeric assembly 1 of PDB entry 3v6r coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3v6r coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 3v6r coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Mitogen-activated protein kinase 10
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Multimeric state: monomeric

PDBe Complex ID: PDB-CPX-156874

$Monomeric assembly 2 of PDB entry 3v6r coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3v6r coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 3v6r coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Mitogen-activated protein kinase 10;</li> <li class='image_legend_li'>1 copy of 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Mitogen-activated protein kinase 10

Chains: A, B
Length: 364 amino acids
Theoretical weight: 42.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: P53779 (Residues: 39-402; Coverage: 78%)

Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Pfam: Protein kinase domain
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Mitogen-activated protein (MAP) kinase, conserved site
Mitogen-activated protein (MAP) kinase, JNK
Serine/threonine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Mitogen-activated protein kinase 10 in PDB entry 3v6r, assembly 1, front view.

Mitogen-activated protein kinase 10 in PDB entry 3v6r, assembly 1, side view.

Mitogen-activated protein kinase 10 in PDB entry 3v6r, assembly 1, top view.

FASTA Sequence


    >pdb|3v6r|A B

MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE

PDBe-KB: UniProt Coverage View: P53779

Molecule details ›

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FASTA (Protein chains A, B)
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Updated mmCIF file
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PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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BLAST P53779 (UniProt)

Protein Data Bank in Europe

Discovery of potent and selective covalent inhibitors of JNK

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 3v6r › Structure analysis

Discovery of potent and selective covalent inhibitors of JNK

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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3v6r › Structure analysis