› 3v5z

X-ray diffraction
2.18Å resolution

Structure of FBXL5 hemerythrin domain, C2 cell, grown anaerobically

Released:
DOI: 10.2210/pdb3v5z/pdb
PDB entry 3v5z coloured by chain, front view.
PDB entry 3v5z coloured by chain, side view.
PDB entry 3v5z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).
Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK
J Biol Chem 287 7357-65 (2012)
PMID: 22253436

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box/LRR-repeat protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UKA1 (Residues: 1-161; Coverage: 23%)
Gene names: FBL4, FBL5, FBXL5, FLR1
Sequence domains: Hemerythrin HHE cation binding domain
Structure domains: nmb1532 protein domain like

Ligands and Environments

1 bound ligand:
Ligand FEO 2 x FEO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 60.442Å b: 76.051Å c: 77.433Å
α: 90° β: 112.12° γ: 90°
R-values:
R R work R free
0.179 0.177 0.223
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

A Red Carpet for Iron Metabolism.
Muckenthaler et al. (2017)
15 more

5 mentions without citation

F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.
Ruiz et al. (2014)
4 more