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Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2

X-ray diffraction
1.85Å resolution
PDB entry 3v2x coloured by chain, front view.
PDB entry 3v2x coloured by chain, side view.
PDB entry 3v2x coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ankyrin repeat family A protein 2 and Low-density lipoprotein receptor-related protein 2
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Multimeric state: hetero dimer
Accessible surface area: 9069.5 Å2
Buried surface area: 1368.51 Å2
Dissociation area: 684.25 Å2
Dissociation energy (ΔGdiss): 5.92 kcal/mol
Dissociation entropy (TΔSdiss): 7.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-161353

Macromolecules

Ankyrin repeat family A protein 2
Chain: A
Length: 167 amino acids
Theoretical weight: 18.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H9E1 (Residues: 148-313; Coverage: 53%)
Gene names: ANKRA, ANKRA2
Pfam:
InterPro:
CATH: Ankyrin repeat-containing domain
Ankyrin repeat family A protein 2 in PDB entry 3v2x, assembly 1, front view.
Ankyrin repeat family A protein 2 in PDB entry 3v2x, assembly 1, side view.
Ankyrin repeat family A protein 2 in PDB entry 3v2x, assembly 1, top view.
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Low-density lipoprotein receptor-related protein 2
Chain: B
Length: 11 amino acids
Theoretical weight: 1.19 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P98158 (Residues: 4455-4465; Coverage: 0%)
Gene name: Lrp2
Low-density lipoprotein receptor-related protein 2 in PDB entry 3v2x, assembly 1, front view.
Low-density lipoprotein receptor-related protein 2 in PDB entry 3v2x, assembly 1, side view.
Low-density lipoprotein receptor-related protein 2 in PDB entry 3v2x, assembly 1, top view.
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