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Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding

Source organism: Rauvolfia serpentina
Biochemical function: oxidoreductase activity
Biological process: alkaloid metabolic process
Cellular component: cytoplasm

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EC 1.1.1.317: Perakine reductase

Reaction catalysed:
Raucaffrinoline + NADP(+) = perakine + NADPH
Systematic name:
Raucaffrinoline:NADP(+) oxidoreductase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00248
Domain description: Aldo/keto reductase family
Occurring in:
  1. Perakine reductase
The deposited structure of PDB entry 3v0t contains 1 copy of Pfam domain PF00248 (Aldo/keto reductase family) in Perakine reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036812
Domain description: NADP-dependent oxidoreductase domain superfamily
Occurring in:
  1. Perakine reductase
IPR023210
Domain description: NADP-dependent oxidoreductase domain
Occurring in:
  1. Perakine reductase

Structure domain

CATH CATH domain
3.20.20.100
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: NADP-dependent oxidoreductase domain
Occurring in:
  1. Perakine reductase
The deposited structure of PDB entry 3v0t contains 1 copy of CATH domain 3.20.20.100 (TIM Barrel) in Perakine reductase. Showing 1 copy in chain A.

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