› 3v0r

X-ray diffraction
1.9Å resolution

Crystal structure of Alternaria alternata allergen Alt a 1

Released:
DOI: 10.2210/pdb3v0r/pdb
PDB 3v0r coloured by chain and viewed from the front.
PDB 3v0r coloured by chain and viewed from the side.
PDB 3v0r coloured by chain and viewed from the top.
Source organism: Alternaria alternata
Primary publication:
Alternaria alternata allergen Alt a 1: A unique ��-barrel protein dimer found exclusively in fungi.
Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomés A, Minor W
J. Allergy Clin. Immunol. (2012)
PMID: 22664167

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major allergen Alt a 1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.61 KDa
Source organism: Alternaria alternata
Expression system: Escherichia coli
UniProt:
  • Canonical: P79085 (Residues: 25-157; Coverage: 96%)
Gene name: ALTA1
Sequence domains: Alternaria alternata allergen 1
Structure domains: AOC barrel-like

Ligands and Environments

4 bound ligands:
Ligand SO4 4 x SO4
Ligand UNX 4 x UNX
Ligand 0FU 3 x 0FU
Ligand 8AC 1 x 8AC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: I4122
Unit cell:
a: 70.016Å b: 70.016Å c: 179.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.167 0.19
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family.
Sánchez et al. (2022)
13 more

2 mentions without citation

Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi.
Chruszcz et al. (2012)
1 more