X-ray diffraction
3.51Å resolution

Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2

Source organism: Bos taurus
Entry authors: Tesmer JJG, Tesmer VM

Function and Biology Details

Reaction catalysed:
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Beta-adrenergic receptor kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 689 amino acids
Theoretical weight: 79.75 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
  • Canonical: P21146 (Residues: 1-689; Coverage: 100%)
Gene names: ADRBK1, GRK2
Sequence domains:
Structure domains:
C13.18 RNA Aptamer Chain: B
Molecule details ›
Chain: B
Length: 18 nucleotides
Theoretical weight: 5.82 KDa
Source organism: Bos taurus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P21212
Unit cell:
a: 113.346Å b: 139.719Å c: 60.949Å
α: 90° β: 90° γ: 90°
R R work R free
0.22 0.216 0.317
Expression systems:
  • Spodoptera frugiperda
  • Not provided