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Crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1.

Source organism: Homo sapiens
Biochemical function: phosphorus-oxygen lyase activity
Biological process: intracellular signal transduction
Cellular component: not assigned

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EC 4.6.1.2: Guanylate cyclase

Reaction catalysed:
GTP = 3',5'-cyclic GMP + diphosphate
Systematic name:
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Alternative Name(s):
  • GTP diphosphate-lyase (cyclizing)
  • Guanyl cyclase
  • Guanylyl cyclase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00211
Domain description: Adenylate and Guanylate cyclase catalytic domain
Occurring in:
  1. Guanylate cyclase soluble subunit alpha-1
  2. Guanylate cyclase soluble subunit beta-1
The deposited structure of PDB entry 3uvj contains 2 copies of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in Guanylate cyclase soluble subunit alpha-1. Showing 1 copy in chain A.
The deposited structure of PDB entry 3uvj contains 2 copies of Pfam domain PF00211 (Adenylate and Guanylate cyclase catalytic domain) in Guanylate cyclase soluble subunit beta-1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001054
Domain description: Adenylyl cyclase class-3/4/guanylyl cyclase
Occurring in:
  1. Guanylate cyclase soluble subunit alpha-1
  2. Guanylate cyclase soluble subunit beta-1
IPR029787
Domain description: Nucleotide cyclase
Occurring in:
  1. Guanylate cyclase soluble subunit alpha-1
  2. Guanylate cyclase soluble subunit beta-1
IPR018297
Domain description: Adenylyl cyclase class-4/guanylyl cyclase, conserved site
Occurring in:
  1. Guanylate cyclase soluble subunit alpha-1
  2. Guanylate cyclase soluble subunit beta-1

Structure domain

CATH CATH domain
3.30.70.1230
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Nucleotide cyclase
Occurring in:
  1. Guanylate cyclase soluble subunit alpha-1
  2. Guanylate cyclase soluble subunit beta-1
The deposited structure of PDB entry 3uvj contains 2 copies of CATH domain 3.30.70.1230 (Alpha-Beta Plaits) in Guanylate cyclase soluble subunit alpha-1. Showing 1 copy in chain A.
The deposited structure of PDB entry 3uvj contains 2 copies of CATH domain 3.30.70.1230 (Alpha-Beta Plaits) in Guanylate cyclase soluble subunit beta-1. Showing 1 copy in chain B.

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