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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

X-ray diffraction
3Å resolution
PDB entry 3uon coloured by chain, front view.
PDB entry 3uon coloured by chain, side view.
PDB entry 3uon coloured by chain, top view.
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endolysin, Muscarinic acetylcholine receptor M2
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Multimeric state: monomeric
Accessible surface area: 21991.11 Å2
Buried surface area: 612.98 Å2
Dissociation area: 171.53 Å2
Dissociation energy (ΔGdiss): -1.25 kcal/mol
Dissociation entropy (TΔSdiss): 2.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132954

Macromolecules

Endolysin; Muscarinic acetylcholine receptor M2
Chain: A
Length: 467 amino acids
Theoretical weight: 52.69 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08172 (Residues: 1-217, 377-466; Coverage: 66%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
    • nullnull
Gene names: CHRM2, E
Pfam:
InterPro:
CATH:
Endolysin in PDB entry 3uon, assembly 1, front view.
Endolysin in PDB entry 3uon, assembly 1, side view.
Endolysin in PDB entry 3uon, assembly 1, top view.
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