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Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.

Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y
Proc Natl Acad Sci U S A 108 21004-9 (2011)
Cited: 49 times
EuropePMC logo PMID: 22158899

Abstract

The mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase, a key component of the Carma1/Bcl10/MALT1 signalosome, is critical for NF-κB signaling in multiple contexts. MALT1 is thought to function as a scaffold and protease to promote signaling; however, the biochemical and structural basis of paracaspase action remains largely unknown. Here we report the 1.75-Å resolution crystal structure of the MALT1 paracaspase region, which contains the paracaspase domain and an ensuing Ig-like domain. The paracaspase and the Ig domains appear as a single folding unit and interact with each other through extensive van der Waals contacts and hydrogen bonds. The paracaspase domain adopts a fold that is nearly identical to that of classic caspases and homodimerizes similarly to form an active protease. Unlike caspases, the active and mature form of the paracaspase domain remains a single uncleaved polypeptide and specifically recognizes the bound peptide inhibitor Val-Arg-Pro-Arg. In particular, the carboxyl-terminal amino acid Arg of the inhibitor is coordinated by three highly conserved acidic residues. This structure serves as an important framework for deciphering the function and mechanism of paracaspases exemplified by MALT1.

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  2. New targets for HIV drug discovery. Puhl AC, Garzino Demo A, Makarov VA, Ekins S. Drug Discov Today 24 1139-1147 (2019)

Articles - 3uo8 mentioned but not cited (4)

  1. Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y. Proc Natl Acad Sci U S A 108 21004-21009 (2011)
  2. Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains. Winter A, Schmid R, Bayliss R. PLoS Comput Biol 11 e1004548 (2015)
  3. Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain. Schairer R, Hall G, Zhang M, Cowan R, Baravalle R, Muskett FW, Coombs PJ, Mpamhanga C, Hale LR, Saxty B, Iwaszkiewicz J, Décaillet C, Perroud M, Carr MD, Thome M. Proc Natl Acad Sci U S A 117 3093-3102 (2020)
  4. Anticancer Activity of Lesbicoumestan in Jurkat Cells via Inhibition of Oxidative Stress-Mediated Apoptosis and MALT1 Protease. Lee JE, Bo F, Thuy NTT, Hong J, Lee JS, Cho N, Yoo HM. Molecules 26 E185 (2021)


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  1. The paracaspase MALT1: biological function and potential for therapeutic inhibition. Jaworski M, Thome M. Cell Mol Life Sci 73 459-473 (2016)
  2. Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. McLuskey K, Mottram JC. Biochem J 466 219-232 (2015)
  3. Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling. Juilland M, Thome M. Front Immunol 9 1927 (2018)
  4. Structural and functional diversity of caspase homologues in non-metazoan organisms. Klemenčič M, Funk C. Protoplasma 255 387-397 (2018)
  5. Evolution and structural diversity of metacaspases. Klemenčič M, Funk C. J Exp Bot 70 2039-2047 (2019)
  6. Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase. Hailfinger S, Lenz G, Thome M. Curr Opin Chem Biol 23 47-55 (2014)
  7. The CBM signalosome: potential therapeutic target for aggressive lymphoma? Yang C, David L, Qiao Q, Damko E, Wu H. Cytokine Growth Factor Rev 25 175-183 (2014)
  8. Protease activity of MALT1: a mystery unravelled. Kirchhofer D, Vucic D. Biochem J 444 e3-5 (2012)
  9. The Paracaspase MALT1 in Cancer. Gomez Solsona B, Schmitt A, Schulze-Osthoff K, Hailfinger S. Biomedicines 10 344 (2022)
  10. Targeted Agents in the Treatment of Indolent B-Cell Non-Hodgkin Lymphomas. Minson A, Tam C, Dickinson M, Seymour JF. Cancers (Basel) 14 1276 (2022)

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  1. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A. Cancer Cell 22 812-824 (2012)
  2. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, Peter von Kries J, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ, Krappmann D. Cancer Cell 22 825-837 (2012)
  3. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H. Mol Cell 51 766-779 (2013)
  4. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Dall E, Brandstetter H. Proc Natl Acad Sci U S A 110 10940-10945 (2013)
  5. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. J Clin Immunol 35 135-146 (2015)
  6. The protease activity of the paracaspase MALT1 is controlled by monoubiquitination. Pelzer C, Cabalzar K, Wolf A, Gonzalez M, Lenz G, Thome M. Nat Immunol 14 337-345 (2013)
  7. Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. David L, Li Y, Ma J, Garner E, Zhang X, Wu H. Proc Natl Acad Sci U S A 115 1499-1504 (2018)
  8. Crystal structure of the yeast metacaspase Yca1. Wong AH, Yan C, Shi Y. J Biol Chem 287 29251-29259 (2012)
  9. Mechanism and specificity of the human paracaspase MALT1. Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS. Biochem J 443 287-295 (2012)
  10. MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses. Yu JW, Hoffman S, Beal AM, Dykon A, Ringenberg MA, Hughes AC, Dare L, Anderson AD, Finger J, Kasparcova V, Rickard D, Berger SB, Ramanjulu J, Emery JG, Gough PJ, Bertin J, Foley KP. PLoS One 10 e0127083 (2015)
  11. New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases. Choi CJ, Berges JA. Cell Death Dis 4 e490 (2013)
  12. Crystal structure of a Trypanosoma brucei metacaspase. McLuskey K, Rudolf J, Proto WR, Isaacs NW, Coombs GH, Moss CX, Mottram JC. Proc Natl Acad Sci U S A 109 7469-7474 (2012)
  13. Structural determinants of MALT1 protease activity. Wiesmann C, Leder L, Blank J, Bernardi A, Melkko S, Decock A, D'Arcy A, Villard F, Erbel P, Hughes N, Freuler F, Nikolay R, Alves J, Bornancin F, Renatus M. J Mol Biol 419 4-21 (2012)
  14. Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase. Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP. Angew Chem Int Ed Engl 52 10384-10387 (2013)
  15. Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. Nie Z, Du MQ, McAllister-Lucas LM, Lucas PC, Bailey NG, Hogaboam CM, Lim MS, Elenitoba-Johnson KS. Nat Commun 6 5908 (2015)
  16. Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth. Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA, Gray NS, Melnick A. J Clin Invest 128 4397-4412 (2018)
  17. Letter Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases. Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV. Mol Cell 77 927-929 (2020)
  18. Orthocaspases are proteolytically active prokaryotic caspase homologues: the case of Microcystis aeruginosa. Klemenčič M, Novinec M, Dolinar M. Mol Microbiol 98 142-150 (2015)
  19. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Quancard J, Klein T, Fung SY, Renatus M, Hughes N, Israël L, Priatel JJ, Kang S, Blank MA, Viner RI, Blank J, Schlapbach A, Erbel P, Kizhakkedathu J, Villard F, Hersperger R, Turvey SE, Eder J, Bornancin F, Overall CM. Nat Chem Biol 15 304-313 (2019)
  20. MALT1 is not alone after all: identification of novel paracaspases. Hulpiau P, Driege Y, Staal J, Beyaert R. Cell Mol Life Sci 73 1103-1116 (2016)
  21. Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas. Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D. Chem Biol 22 129-138 (2015)
  22. Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface. Cabalzar K, Pelzer C, Wolf A, Lenz G, Iwaszkiewicz J, Zoete V, Hailfinger S, Thome M. PLoS One 8 e72051 (2013)
  23. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, Gul IS, Sundararaman S, Gonçalves A, Dhondt I, Pinzón JH, Braeckman BP, Technau U, Saeys Y, van Roy F, Beyaert R. Front Immunol 9 1136 (2018)
  24. Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2. Machado MF, Marcondes MF, Juliano MA, McLuskey K, Mottram JC, Moss CX, Juliano L, Oliveira V. FEBS J 280 2608-2621 (2013)
  25. Probes to monitor activity of the paracaspase MALT1. Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS. Chem Biol 22 139-147 (2015)
  26. Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. McLuskey K, Grewal JS, Das D, Godzik A, Lesley SA, Deacon AM, Coombs GH, Elsliger MA, Wilson IA, Mottram JC. J Biol Chem 291 9482-9491 (2016)
  27. Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Positively Modulates Matrix Metalloproteinase-9 Production in Alveolar Macrophages upon Toll-Like Receptor 7 Signaling and Influenza Virus Infection. Lee YH, Huang JH, Chang TH, Yang HC, Wu-Hsieh BA. Front Immunol 8 1177 (2017)
  28. A two-step activation mechanism of MALT1 paracaspase. Staal J, Beyaert R. J Mol Biol 419 1-3 (2012)
  29. Activity-based probes trap early active intermediates during metacaspase activation. Štrancar V, van Midden KP, Krahn D, Morimoto K, Novinec M, Funk C, Stael S, Schofield CJ, Klemenčič M, van der Hoorn RAL. iScience 25 105247 (2022)
  30. Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL3 domain in solution. Han X, Levkovets M, Lesovoy D, Sun R, Wallerstein J, Sandalova T, Agback T, Achour A, Agback P, Orekhov VY. Biomol NMR Assign 16 363-371 (2022)
  31. BCL10GFP fusion protein as a substrate for analysis of determinants required for mucosa-associated lymphoid tissue 1 (MALT1)-mediated cleavage. Jou SY, Chang CC, Wu CH, Chen MR, Tsai CH, Chuang WH, Chen YH, Cheng AL, Doong SL. J Biomed Sci 19 85 (2012)
  32. Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 in oral carcinoma cells and gingival fibroblasts. Oyama G, Midorikawa T, Matsumoto Y, Takeyama M, Yamada K, Nozawa T, Morikawa M, Imai K. Odontology 101 150-155 (2013)
  33. Insights Into the Phylogenetic Distribution, Diversity, Structural Attributes, and Substrate Specificity of Putative Cyanobacterial Orthocaspases. Bhattacharjee S, Kharwar S, Mishra AK. Front Microbiol 12 682306 (2021)


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