X-ray diffraction
2.56Å resolution

Crystal Structure of Human GAC in Complex with Glutamate

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
L-glutamine + H(2)O = L-glutamate + NH(3)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glutaminase kidney isoform, mitochondrial 65 kDa chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 534 amino acids
Theoretical weight: 58.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O94925 (Residues: 71-600; Coverage: 79%)
  • Best match: O94925-3 (Residues: 71-598)
Gene names: GLS, GLS1, KIAA0838
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 50.66Å b: 139.614Å c: 178.385Å
α: 90° β: 94.14° γ: 90°
R R work R free
0.228 0.226 0.261
Expression system: Not provided