3uii › Citations

Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.

Du J, Kelly AE, Funabiki H, Patel DJ
Structure 20 185-95 (2012)
Related entries: 3uig, 3uih, 3uij, 3uik

Cited: 42 times
EuropePMC logo PMID: 22244766

Abstract

Survivin is an inhibitor of apoptosis family protein implicated in apoptosis and mitosis. In apoptosis, it has been shown to recognize the Smac/DIABLO protein. It is also a component of the chromosomal passenger complex, a key player during mitosis. Recently, Survivin was identified in vitro and in vivo as the direct binding partner for phosphorylated Thr3 on histone H3 (H3T3ph). We have undertaken structural and binding studies to investigate the molecular basis underlying recognition of H3T3ph and Smac/DIABLO N-terminal peptides by Survivin. Our crystallographic studies establish recognition of N-terminal Ala in both complexes and identify intermolecular hydrogen-bonding interactions in the Survivin phosphate-binding pocket that contribute to H3T3ph mark recognition. In addition, our calorimetric data establish that Survivin binds tighter to the H3T3ph-containing peptide relative to the N-terminal Smac/DIABLO peptide, and this preference can be reversed through structure-guided mutations that increase the hydrophobicity of the phosphate-binding pocket.

Articles - 3uii mentioned but not cited (2)

  1. Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Du J, Kelly AE, Funabiki H, Patel DJ. Structure 20 185-195 (2012)
  2. Data on docking of phytoconstituents of Actinidia deliciosa on dengue viral targets. Chandani SR, Lokhande KB, Swamy KV, Nanda RK, Chitlange SS. Data Brief 25 103996 (2019)


Reviews citing this publication (10)

  1. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Carmena M, Wheelock M, Funabiki H, Earnshaw WC. Nat Rev Mol Cell Biol 13 789-803 (2012)
  2. Perceiving the epigenetic landscape through histone readers. Musselman CA, Lalonde ME, Côté J, Kutateladze TG. Nat Struct Mol Biol 19 1218-1227 (2012)
  3. Readout of epigenetic modifications. Patel DJ, Wang Z. Annu Rev Biochem 82 81-118 (2013)
  4. The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Krenn V, Musacchio A. Front Oncol 5 225 (2015)
  5. Histone modifications and mitosis: countermarks, landmarks, and bookmarks. Wang F, Higgins JM. Trends Cell Biol 23 175-184 (2013)
  6. Survivin - The inconvenient IAP. Altieri DC. Semin Cell Dev Biol 39 91-96 (2015)
  7. Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma. Khan Z, Khan AA, Yadav H, Prasad GBKS, Bisen PS. Cell Mol Biol Lett 22 8 (2017)
  8. IAPs: Modular regulators of cell signalling. Budhidarmo R, Day CL. Semin Cell Dev Biol 39 80-90 (2015)
  9. A Condensed View of the Chromosome Passenger Complex. Trivedi P, Stukenberg PT. Trends Cell Biol 30 676-687 (2020)
  10. Establishing correct kinetochore-microtubule attachments in mitosis and meiosis. Cairo G, Lacefield S. Essays Biochem 64 277-287 (2020)

Articles citing this publication (30)

  1. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. De Antoni A, Maffini S, Knapp S, Musacchio A, Santaguida S. J Cell Biol 199 269-284 (2012)
  2. Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT. Mol Biol Cell 23 1457-1466 (2012)
  3. The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. Trivedi P, Palomba F, Niedzialkowska E, Digman MA, Gratton E, Stukenberg PT. Nat Cell Biol 21 1127-1137 (2019)
  4. Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis. Hadders MA, Hindriksen S, Truong MA, Mhaskar AN, Wopken JP, Vromans MJM, Lens SMA. J Cell Biol 219 e201907087 (2020)
  5. EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. Banerjee B, Kestner CA, Stukenberg PT. J Cell Biol 204 947-963 (2014)
  6. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Baron AP, von Schubert C, Cubizolles F, Siemeister G, Hitchcock M, Mengel A, Schröder J, Fernández-Montalván A, von Nussbaum F, Mumberg D, Nigg EA. Elife 5 e12187 (2016)
  7. Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation. Liang C, Zhang Z, Chen Q, Yan H, Zhang M, Zhou L, Xu J, Lu W, Wang F. J Cell Biol 219 e201907092 (2020)
  8. A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F. EMBO Rep 19 43-56 (2018)
  9. Recent Advances on Small-Molecule Survivin Inhibitors Xiao M, Li W. Curr Med Chem 22 1136 - 1146 (2015)
  10. Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Gatchalian J, Gallardo CM, Shinsky SA, Ospina RR, Liendo AM, Krajewski K, Klein BJ, Andrews FH, Strahl BD, M van Wely KH, Kutateladze TG. Nucleic Acids Res 44 6102-6112 (2016)
  11. Withanone as an inhibitor of survivin: a potential drug candidate for cancer therapy. Wadegaonkar VP, Wadegaonkar PA. J Biotechnol 168 229-233 (2013)
  12. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. Wang J, Li W. J Pharmacol Exp Ther 349 319-329 (2014)
  13. Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6. Andersson KM, Brisslert M, Cavallini NF, Svensson MN, Welin A, Erlandsson MC, Ciesielski MJ, Katona G, Bokarewa MI. Oncotarget 6 20043-20057 (2015)
  14. Modulation of Respiration and Mitochondrial Dynamics by SMAC-Mimetics for Combination Therapy in Chemoresistant Cancer. Hagenbuchner J, Oberacher H, Arnhard K, Kiechl-Kohlendorfer U, Ausserlechner MJ. Theranostics 9 4909-4922 (2019)
  15. Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle. Serena M, Bastos RN, Elliott PR, Barr FA. J Cell Biol 219 e201910059 (2020)
  16. The structure of XIAP BIR2: understanding the selectivity of the BIR domains. Lukacs C, Belunis C, Crowther R, Danho W, Gao L, Goggin B, Janson CA, Li S, Remiszewski S, Schutt A, Thakur MK, Singh SK, Swaminathan S, Pandey R, Tyagi R, Gosu R, Kamath AV, Kuglstatter A. Acta Crystallogr D Biol Crystallogr 69 1717-1725 (2013)
  17. Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. Huang M, Feng X, Su D, Wang G, Wang C, Tang M, Paulucci-Holthauzen A, Hart T, Chen J. Oncogene 39 4312-4322 (2020)
  18. The Borealin dimerization domain interacts with Sgo1 to drive Aurora B-mediated spindle assembly. Bonner MK, Haase J, Saunders H, Gupta H, Li BI, Kelly AE. Mol Biol Cell 31 2207-2218 (2020)
  19. Focused grid-based resampling for protein docking and mapping. Mamonov AB, Moghadasi M, Mirzaei H, Zarbafian S, Grove LE, Bohnuud T, Vakili P, Ch Paschalidis I, Vajda S, Kozakov D. J Comput Chem 37 961-970 (2016)
  20. Haspin-dependent and independent effects of the kinase inhibitor 5-Iodotubercidin on self-renewal and differentiation. Karanika E, Soupsana K, Christogianni A, Stellas D, Klinakis A, Politou AS, Georgatos S. Sci Rep 10 232 (2020)
  21. Effects of a combined therapy of bortezomib and ionizing radiation on chondrosarcoma three-dimensional spheroid cultures. Lohberger B, Glaenzer D, Eck N, Steinecker-Frohnwieser B, Leithner A, Rinner B, Kerschbaum-Gruber S, Georg D. Oncol Lett 21 428 (2021)
  22. Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC. Abad MA, Gupta T, Hadders MA, Meppelink A, Wopken JP, Blackburn E, Zou J, Gireesh A, Buzuk L, Kelly DA, McHugh T, Rappsilber J, Lens SMA, Jeyaprakash AA. J Cell Biol 221 e202108156 (2022)
  23. Epigenetic Reprogramming of the Glucose Metabolic Pathways by the Chromatin Effectors During Cancer. Mondal P, Tiwary N, Sengupta A, Dhang S, Roy S, Das C. Subcell Biochem 100 269-336 (2022)
  24. Nucleosome-Dependent Pathways That Control Mitotic Progression. Funabiki H, Jenness C, Zierhut C. Cold Spring Harb Symp Quant Biol 82 173-185 (2017)
  25. Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Hashimoto H, Ramirez DH, Lautier O, Pawlak N, Blobel G, Palancade B, Debler EW. Sci Rep 12 17691 (2022)
  26. Synthesis and antitumor activity evaluation of asiatic acid derivatives as survivin inhibitor. Meng YQ, Cui HB, Li L, Zhang WC, Pan HS, Yu TT, Li W. J Asian Nat Prod Res 20 897-908 (2018)
  27. Halogen Bonding in Haspin-Halogenated Tubercidin Complexes: Molecular Dynamics and Quantum Chemical Calculations. Zhou Y, Wong MW. Molecules 27 706 (2022)
  28. Histone Readers and Their Roles in Cancer. Wen H, Shi X. Cancer Treat Res 190 245-272 (2023)
  29. Neferine Targets the Oncogenic Characteristics of Androgen-Dependent Prostate Cancer Cells via Inducing Reactive Oxygen Species. Dasari S, Pathak N, Thomas A, Bitla S, Kumar R, Munirathinam G. Int J Mol Sci 24 14242 (2023)
  30. Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27. Jensen M, Chandrasekaran V, García-Bonete MJ, Li S, Anindya AL, Andersson K, Erlandsson MC, Oparina NY, Burmann BM, Brath U, Panchenko AR, Bokarewa I M, Katona G. iScience 26 106976 (2023)


Quick links