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Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-((5-(6-aminopyridin-2-yl)pentyl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

X-ray diffraction
2Å resolution
PDB entry 3ufw coloured by chain, front view.
PDB entry 3ufw coloured by chain, side view.
PDB entry 3ufw coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nitric oxide synthase 1
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Multimeric state: homo dimer
Accessible surface area: 33197.08 Å2
Buried surface area: 9958.85 Å2
Dissociation area: 68.07 Å2
Dissociation energy (ΔGdiss): 40.71 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151520

Macromolecules

Nitric oxide synthase 1
Chains: A, B
Length: 422 amino acids
Theoretical weight: 48.81 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29476 (Residues: 297-718; Coverage: 30%)
Gene names: Bnos, Nos1
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
CATH:
Nitric oxide synthase 1 in PDB entry 3ufw, assembly 1, front view.
Nitric oxide synthase 1 in PDB entry 3ufw, assembly 1, side view.
Nitric oxide synthase 1 in PDB entry 3ufw, assembly 1, top view.
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