X-ray diffraction
2.75Å resolution

Crystal structure of the human Colony-Stimulating Factor 1 (hCSF-1) cytokine


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Processed macrophage colony-stimulating factor 1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 153 amino acids
Theoretical weight: 17.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P09603 (Residues: 33-181; Coverage: 29%)
Gene name: CSF1
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 61.15Å b: 104.49Å c: 116.24Å
α: 90° β: 105.29° γ: 90°
R R work R free
0.142 0.137 0.19
Expression system: Escherichia coli