› 3ubh

X-ray diffraction
2.7Å resolution

Crystal structure of Drosophila N-cadherin EC1-4

Released:
DOI: 10.2210/pdb3ubh/pdb
PDB 3ubh coloured by chain and viewed from the front.
PDB 3ubh coloured by chain and viewed from the side.
PDB 3ubh coloured by chain and viewed from the top.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca��+-free interdomain linkers.
Jin X, Walker MA, Fels��v��lyi K, Vendome J, Bahna F, Mannepalli S, Cosmanescu F, Ahlsen G, Honig B, Shapiro L
Proc. Natl. Acad. Sci. U.S.A. 109 E127-34 (2012)
PMID: 22171007

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural-cadherin Chain: A
Molecule details ›
Chain: A
Length: 419 amino acids
Theoretical weight: 47.43 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: O15943 (Residues: 434-851; Coverage: 14%)
Gene names: CG7100, CadN
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21212
Unit cell:
a: 81.499Å b: 126.656Å c: 62.009Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.276
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
3 more

2 mentions without citation

Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.
Jin et al. (2012)
1 more