› 3ubf

X-ray diffraction
2.5Å resolution

Crystal structure of Drosophila N-cadherin EC1-3, I

Released:
DOI: 10.2210/pdb3ubf/pdb
PDB entry 3ubf coloured by chain, front view.
PDB entry 3ubf coloured by chain, side view.
PDB entry 3ubf coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca²+-free interdomain linkers.
Jin X, Walker MA, Felsövályi K, Vendome J, Bahna F, Mannepalli S, Cosmanescu F, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 109 E127-34 (2012)
PMID: 22171007

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-127553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neural-cadherin Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.93 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: O15943 (Residues: 439-753; Coverage: 10%)
Gene names: CG7100, CadN
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand ZN 18 x ZN
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P6222
Unit cell:
a: 96.289Å b: 96.289Å c: 148.196Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.201 0.279
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
4 more

2 mentions without citation

Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells.
Yang et al. (2014)
1 more