› 3u6n

X-ray diffraction
3.61Å resolution

Open Structure of the BK channel Gating Ring

Released:
DOI: 10.2210/pdb3u6n/pdb
PDB entry 3u6n coloured by chain, front view.
PDB entry 3u6n coloured by chain, side view.
PDB entry 3u6n coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.
Yuan P, Leonetti MD, Hsiung Y, MacKinnon R
Nature 481 94-7 (2011)
PMID: 22139424

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-110656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel subunit alpha-1a Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 696 amino acids
Theoretical weight: 78.69 KDa
Source organism: Danio rerio
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: B7ZC96 (Residues: 360-597, 598-1075; Coverage: 58%)
Gene name: kcnma1a
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 137.648Å b: 210.816Å c: 238.758Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.26 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

28 review citations

Molecular Determinants of BK Channel Functional Diversity and Functioning.
Latorre et al. (2017)
27 more

17 mentions without citation

Structure of potassium channels.
Kuang et al. (2015)
16 more