X-ray diffraction
2.3Å resolution

Crystal structure of Human SULT1A1 bound to PAP and 3-Cyano-7-hydroxycoumarin


Function and Biology Details

Reaction catalysed:
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Sulfotransferase 1A1 Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 36.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P50225 (Residues: 1-295; Coverage: 100%)
Gene names: OK/SW-cl.88, STP, STP1, SULT1A1
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 72.634Å b: 122.781Å c: 44.764Å
α: 90° β: 90° γ: 90°
R R work R free
0.196 0.194 0.235
Expression system: Escherichia coli BL21(DE3)