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Aprotinin bound to Dengue virus protease

Source organisms:
Biochemical function: serine-type endopeptidase inhibitor activity
Biological process: not assigned
Cellular component: virion component

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.91: Flavivirin

Reaction catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Alternative Name(s):
  • NS2B-3 proteinase
  • Yellow fever virus (flavivirus) protease
  • Yellow fever virus protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00014
Domain description: Kunitz/Bovine pancreatic trypsin inhibitor domain
Occurring in:
  1. Pancreatic trypsin inhibitor
The deposited structure of PDB entry 3u1j contains 1 copy of Pfam domain PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) in Pancreatic trypsin inhibitor. Showing 1 copy in chain C [auth E].

PF00949
Domain description: Peptidase S7, Flavivirus NS3 serine protease
Occurring in:
  1. Serine protease NS3
The deposited structure of PDB entry 3u1j contains 1 copy of Pfam domain PF00949 (Peptidase S7, Flavivirus NS3 serine protease ) in Serine protease NS3. Showing 1 copy in chain B.

PF01002
Domain description: Flavivirus non-structural protein NS2B
Occurring in:
  1. Serine protease subunit NS2B
The deposited structure of PDB entry 3u1j contains 1 copy of Pfam domain PF01002 (Flavivirus non-structural protein NS2B) in Serine protease subunit NS2B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002223
Domain description: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR036880
Domain description: Pancreatic trypsin inhibitor Kunitz domain superfamily
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR001850
Domain description: Non-structural protein NS3, peptidase S7, flavivirus
Occurring in:
  1. Serine protease NS3
IPR000487
Domain description: Non-structural protein NS2B, flavivirus
Occurring in:
  1. Serine protease subunit NS2B
IPR020901
Domain description: Proteinase inhibitor I2, Kunitz, conserved site
Occurring in:
  1. Pancreatic trypsin inhibitor
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Serine protease NS3
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Serine protease NS3

Structure domains

CATH CATH domains
4.10.410.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Factor Xa Inhibitor
Homology: Pancreatic trypsin inhibitor Kunitz domain
Occurring in:
  1. Pancreatic trypsin inhibitor
The deposited structure of PDB entry 3u1j contains 1 copy of CATH domain 4.10.410.10 (Factor Xa Inhibitor) in Pancreatic trypsin inhibitor. Showing 1 copy in chain C [auth E].
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Serine protease NS3
The deposited structure of PDB entry 3u1j contains 1 copy of CATH domain 2.40.10.10 (Thrombin, subunit H) in Serine protease NS3. Showing 1 copy in chain B.
2.40.10.120
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Thrombin, subunit H
Occurring in:
  1. Serine protease NS3
The deposited structure of PDB entry 3u1j contains 1 copy of CATH domain 2.40.10.120 (Thrombin, subunit H) in Serine protease NS3. Showing 1 copy in chain B.

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