X-ray diffraction
2.3Å resolution

Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UL51 (Residues: 470-672; Coverage: 23%)
Gene names: BCNG2, HCN2
Sequence domains: Cyclic nucleotide-binding domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P4212
Unit cell:
a: 96.73Å b: 96.73Å c: 50.79Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.2 0.272
Expression system: Escherichia coli