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Crystal structure of the complex of Human Chromobox Homolog 3 (CBX3)

X-ray diffraction
1.81Å resolution
PDB entry 3tzd coloured by chain, front view.
PDB entry 3tzd coloured by chain, side view.
PDB entry 3tzd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Chromobox protein homolog 3 and Histone H1.4
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Multimeric state: hetero dimer
Accessible surface area: 4896.84 Å2
Buried surface area: 1563.42 Å2
Dissociation area: 781.71 Å2
Dissociation energy (ΔGdiss): 7.13 kcal/mol
Dissociation entropy (TΔSdiss): 7.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145297

Macromolecules

Chromobox protein homolog 3
Chain: A
Length: 58 amino acids
Theoretical weight: 6.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13185 (Residues: 29-81; Coverage: 29%)
Gene name: CBX3
Pfam: Chromo (CHRromatin Organisation MOdifier) domain
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Chromobox protein homolog 3 in PDB entry 3tzd, assembly 1, front view.
Chromobox protein homolog 3 in PDB entry 3tzd, assembly 1, side view.
Chromobox protein homolog 3 in PDB entry 3tzd, assembly 1, top view.
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Histone H1.4
Chain: T
Length: 19 amino acids
Theoretical weight: 2.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10412 (Residues: 19-36; Coverage: 8%)
Gene names: H1-4, H1F4, HIST1H1E
Histone H1.4 in PDB entry 3tzd, assembly 1, front view.
Histone H1.4 in PDB entry 3tzd, assembly 1, side view.
Histone H1.4 in PDB entry 3tzd, assembly 1, top view.
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