› 3tt8

X-ray diffraction
1.12Å resolution

Crystal Structure Analysis of Cu Human Insulin Derivative

Released:
DOI: 10.2210/pdb3tt8/pdb
PDB 3tt8 coloured by chain and viewed from the front.
PDB 3tt8 coloured by chain and viewed from the side.
PDB 3tt8 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Prugovecki B, Matkovic-Calogovic D

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

1 bound ligand:
Ligand CU 2 x CU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: R3
Unit cell:
a: 81.56Å b: 81.56Å c: 33.747Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.135 0.132 0.179
Expression system: Not provided

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